November 30, 2021

Southern Africa-Linked COVID-19 Variant With ‘Horrific’ Number of Spike Mutations Triggers Concerns

According to the World Health Organisation, all viruses, including SARS-CoV-2, that causes COVID-19, change, but only some deviations affect their properties, such as the speed with which it spreads, the associated severity of disease, and the effectiveness of vaccines. The Delta variant, detected a year ago, is now dominant around the world. A new  COVID-19  variant with an […]#@@#@!!

According to the World Health Organisation, all viruses, including SARS-CoV-2, that triggers COVID-19, change, but just some deviations affect their own properties, such as the speed which it spreads, the linked severity of disease, as well as the effectiveness of vaccines.

The Delta variant, detected a year ago, is now dominant across the globe. A new  COVID-19   variant with an “ extremely high” number of variations in the spike protein provides alarmed scientists due to its potential to dodge antibodies that can fight  the virus .  

The particular B. 1 . 1 . 529 strain is described as an offshoot of an earlier variant called B. 1 . one and has 32 spike variations. In comparison, the Delta version that is currently dominant around the world has 16.

The spike protein is the part of the virus that most existing  coronavirus vaccines   use to allow the immune system to fight the infectious disease caused by the SARS-CoV-2 virus.  

Dr Tom Peacock, a virologist at Imperial College London, noted the “ incredibly high amount of spike mutations suggest this might be of real concern”, when he posted details of the new variant on a genome-sharing  site .

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He subsequently continued Twitter to strongly urge that this COVID-19 variant become “ very, very much supervised due to that horrific spike profile”, while at the same time adding it may turn out to be an “ odd cluster” that is not very transmissible. “ I really hope that’s the case, ” he wrote.

Mutations can not only impact the virus’s ability to infect cells and spread, but also make it harder for immune cells to attack the pathogen. So far only 10 cases of the variant have been spotted through genomic sequencing in South Africa, Botswana and one case in Hong Kong, where the individual in question had recently travelled to South Africa.

The first of the Botswana cases emerged on 11 November, the South Africa cases emerged on 14 November.

New Variant of COVID-19 Delta Strain Detected in Norway, Reports Say 15 November, 12: 47 GMTRavi Gupta, a professor of clinical microbiology at Cambridge University, told Science Media Centre (SMC)  press office   that studies at his lab discovered that two of the spike mutations on B. 1 ) 1 . 529 increased infectivity and reduced antibody recognition.  

“ It does certainly look an important concern based on the mutations present. However , a key property of the virus that is unknown is its infectiousness, as that is what appears to have primarily driven the Delta variant. Immune escape is only part of the picture of what may happen. ”  

Prof Francois Balloux, Professor of Computational Systems Biology and Director, UCL Genetics Institute, is of the opinion that the variant’s mutations are in “ an unusual constellation” that “ accummulated apparently in a single burst”.  

According to Balloux, the variant could have evolved during a “ chronic infection of an immunocompromised person, possibly in an untreated HIV/AIDS patient”.

Prof Balloux conceded that it was difficult to predict how transmissible the new variant might be.   “ So far, four strains have been sequenced in a region of Sub-Saharan with reasonable surveillance in place.

It may be within other parts of Africa. For the moment, it should be closely monitored and analysed, but there is no reason to get overly concerned, unless it starts going up in frequency in the near future, ” that he stated.  

It is believed that the governments where the new coronavirus variant has been identified, in South Africa, Botswana and Hong Kong, understand the cases.    

The Delta variant   of Sars-CoV-2, since it was initially detected in India in December 2020, has become globally dominant. According to the World Health Organization, 99. 5% of most COVID-19 genomic sequences reported to public databases are actually Delta. The question remains whether some potentially more ominous variant might be looming in the future.

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