mRNA Vaccines Significantly Associated With Fatal Blood Clots, Major Study Finds

Blood-clotting condition cerebral venous thrombosis (CVT), which can cause serious neurological damage, will be significantly associated with mRNA Covid vaccination, a major  study  in leading medical journal  Vaccines  has found. The investigation team analysed 1, 154, 023 adverse event reports from more than 130 countries logged with VigiBase, the planet Health Organisation’ s global deduplicated database, and found a “ potential basic safety signal for CVT […]#@@#@!!

Blood-clotting condition cerebral venous thrombosis (CVT), which can cause serious neurological damage, is significantly associated with mRNA Covid vaccination, the major  study   in leading healthcare journal  Vaccines  has found.

The research team analysed 1, 154, 023 undesirable event reports from over 130 countries logged along with VigiBase, the World Health Organisation’s global deduplicated database, and found a “ potential safety signal for CVT occurrence after COVID-19 mRNA vaccination”.

The particular authors note many reviews were in younger individuals and the conditions were severe: “ CVTs were typically reported in patients elderly 18-44 and 45-64 years, more frequently in women, and mainly in Europe plus America… More than 90% of the patients were in serious condition, and 33% failed to recover or died. ”

The scientists take into account under-reporting to produce estimations of increased risk over a baseline: around 3. five times greater risk for mRNA vaccines and seven times greater risk for AstraZeneca. This means the CVT danger from mRNA vaccines, whilst high, is around half those of AstraZeneca.

In addition they found that CVT following mRNA vaccination is only around a third as deadly because that following AstraZeneca vaccination. This means mRNA vaccines lead to deadly CVT around a 6th as often as AstraZeneca, which might explain why the condition is particularly associated with the AstraZeneca jab.

The researchers cite earlier studies to recommend the mechanism relates to the spike protein binding to the wall of blood vessels, especially in the brain, and activating clotting mechanisms.

There are few reports on CVT after mRNA-based COVID-19 vaccination. These research suggested that CVT situations related to mRNA-based COVID-19 vaccines may be due to endothelial disorder caused by spike glycoprotein connections with endothelial cells leading to immunothrombosis. If the spike glycoprotein of mRNA-based COVID-19 vaccines binds to the angiotensin-converting enzyme 2 receptor, several inflammatory and thrombogenic molecules, like leukocyte chemotactic factors, cellular adhesion molecules (vascular cellular adhesion molecule 1 plus intercellular adhesion molecule 1), and procoagulant cytokines, could be activated. This mechanism could cause endothelial dysfunction, particularly within brain endothelial cells, that could contribute to a significant disruption associated with brain endothelial barrier ethics, ultimately promoting thrombus formation. Moreover, a previous research suggested that the spike glycoprotein may induce platelet aggregation and activation and eventually result in thrombus formation. Although the time period in which the spike glycoprotein persists has not been clearly established, a number of studies have suggested that it may last for weeks. Thus, spike glycoprotein-related platelet activation triggered by mRNA-based COVID-19 vaccines could explain fashionable of CVT occurrences right after mRNA-based COVID-19 vaccinations. Moreover, in line with these previous case reports, our results showed that CVT occurred generally within a few weeks of mRNA-based COVID-19 vaccinations.

Here is the study summary, summarising the findings.

Cerebral venous thrombosis (CVT), a rare thrombotic event that can cause serious neurologic deficits, has been reported after some ChAdOx1  [AstraZeneca]   nCoV-19 vaccinations against coronavirus disease 2019 (COVID-19). However , there are few reviews of associations between COVID-19 mRNA vaccination and CVT. We retrospectively analysed CVT occurrence, time of onset after vaccination, outcomes (recovered/not recovered), and death after COVID-19 vaccination from adverse drug reactions (ADR) reports in VigiBase. A disproportionality evaluation was performed regarding COVID-19 mRNA vaccines (BNT162b2 [Pfizer] and mRNA-1273 [Moderna]) and the ChAdOx1 nCoV-19 vaccine. All of us identified 756 (0. 07%) CVT cases (620 (0. 05%) after BNT162b2 plus 136 (0. 01%) right after mRNA-1273) of 1, 154, 023 mRNA vaccine-related ADRs. Significant positive safety signals were noted for COVID-19 mRNA vaccines (95% lower end of information component = 1 . 56; reporting odds ratio along with 95% confidence interval (CI) = 3. 27). The particular median days to CVT onset differed significantly between your BNT162b2 and ChAdOx1 nCoV-19 vaccines (12 (interquartile range, 3-22) and 11 (interquartile range, 7-16), respectively;   p   = 0. 02). Less CVT patients died after receiving mRNA vaccines compared to after receiving the ChAdOx1 nCoV-19 vaccine (odds percentage, 0. 32; 95% CI, 0. 22– 0. forty five;   p   < 0. 001). We noted a potential security signal for CVT incident after COVID-19 mRNA vaccination. Therefore , awareness about the risk of CVT, even after COVID-19 mRNA vaccination, is necessary.

The organization of blood-clotting adverse reactions with adenovirus vector vaccines such as AstraZeneca and Johnson plus Johnson have led to them being restricted or taken in many countries, most recently with the U. S.   FDA . The fact that this adverse reaction is also connected with mRNA vaccines, albeit in a somewhat less deadly form, suggests that the differential remedying of the two vaccine types with this basis is unlikely to be tenable.

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