Having antibodies against COVID-19 provides children with little or no protection against infection, a study published in JAMA has found.
Rather, the main determinant of safety is cellular immunity (i. e., T cells). Worse, against Omicron having antibodies actually increased the risk of infection, which may assistance to explain the unfavorable vaccine effectiveness seen in a number of studies , where contamination rates are higher in the vaccinated than the unvaccinated.
The study assessed defense against SARS-CoV-2 infection in 79 children aged four in order to 11 years in England. The final results are depicted below.
Notice that both cellular-positive bars (pink and beige) are much lower than the two cellular-negative bars. This implies that being cellular positive required much lower infection risk than being cellular negative, whether or not the person had antibodies (i. e., was seropositive). Getting antibodies here did result in a slightly reduced risk associated with infection, but not much.
The chart above shows the infections over time. Probably the most striking aspect is the large green column in January for Omicron, which is for that cellular-negative. Note also that the pink bar in The month of january is slightly higher than the particular beige bar. The red bar is antibody-positive whereas the beige bar is just not (both are cellular positive), suggesting antibodies here were a disadvantage against Omicron.
This particular unexpected result is confirmed in the next chart (above) to get Omicron, which shows chlamydia risk in the seropositive (pink) considerably higher than the seronegative (beige) among the cellular-positive. This means that while T cells had been highly protective against Omicron, antibodies appear to have been anti-protective (or at least coincided along with something anti-protective).
The authors remark that these results are important in light of results showing the Pfizer vaccine offering just 11% protection for children elderly five to 11 against Omicron – far less compared to protection indicated here simply by cellular immunity. The authors might also have noted studies which find negative vaccine efficacy , which fit with the anti-protection from antibodies observed here.
The authors note that an earlier study had found that around two thirds of kids aged four to 11 who tested negative just for antibodies nonetheless had cellular responses against SARS-CoV-2 spike protein, and such cellular reactions were even present in four pre-pandemic samples. This is yet further indication that kids gain little or nothing from Covid vaccination (both before and after infection). Yet they do bear the adverse effects , with one recent study finding up to a single in every 500 children outdated under five being hospitalised by the Pfizer jab.